University of North Carolina at Chapel Hill · GeneticsOzone Impact and Genetics Lab
Samir Kelada · Chapel Hill, North Carolina
Research Focus
Dr. Samir Kelada's lab at the University of North Carolina Chapel Hill focuses on understanding how genetic differences affect individual responses to environmental air pollutants, specifically ozone. The research aims to uncover the mechanisms underlying respiratory diseases like asthma and COPD, which are exacerbated by ozone exposure. By studying human bronchial epithelial cells and using genetically diverse mouse models, the lab seeks to identify genetic variants and gene regulatory mechanisms that contribute to differences in disease susceptibility.
ozone pollutionrespiratory healthgene-environment interactionsepigeneticsasthmaCOPDinflammationgene regulationmulti-omicstranscriptomics
Research Aims
5AIM 01Identify genetic variants affecting ozone-induced airway inflammation.
AIM 02Characterize gene expression changes in epithelial cells exposed to ozone.
AIM 03Understand how genetic diversity in mice influences responses to ozone exposure.
AIM 04Discover mechanisms of adaptation to ozone exposure in macrophages.
AIM 05Develop new insights into susceptibility to chronic lung diseases caused by ozone.
Skills the Lab Values
cell cultureRNA sequencingATAC-seqgenotypingmouse modelsbioinformaticschromatin accessibility assaysdata integrationwestern blotflow cytometry
Output against the department
Publications79bottom 22% of dept.200th of 259
this lab
most publishedleast published
Citations1.2kbottom 6% of dept.244th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.