EUEmory University · Biology
Rowan Neurobiology Lab
Matthew J.M. Rowan · Atlanta, Georgia
Research Focus
Dr. Matthew J.M. Rowan's lab at Emory University focuses on the intricate biology of Alzheimer's disease, particularly how specific brain cells called parvalbumin-expressing interneurons malfunction as the disease progresses. Using advanced robotic technology, his team examines how these cellular changes correlate with cognitive decline and the early indicators of Alzheimer's. The ultimate goal is to develop innovative therapeutic strategies to address circuit dysfunction and improve outcomes for patients with dementia.
Alzheimer's Diseasecell-type-specific electrophysiologycircuit dysregulationneurodegenerationGABAergic interneuronsearly diagnosisrobotic electrophysiology
Research Aims
5AIM 01Investigate the early physiological deficits of parvalbumin-expressing interneurons in Alzheimer's disease.
AIM 02Use high-throughput robotic systems to record electrical activity from neurons.
AIM 03Explore the relationship between circuit hyperexcitability and cognitive decline in Alzheimer's models.
AIM 04Identify critical brain regions where dysfunction in PV interneurons occurs first in the progression of Alzheimer's disease.
AIM 05Develop new technologies to advance the understanding of cellular dysfunction in early Alzheimer's disease.
Skills the Lab Values
electrophysiologyrobotics in neuroscienceimaging for neuron identificationneuron patch clampinganimal models of diseasefluorescence microscopyoptogeneticscell culturedata analysis in neurosciencebiological marker detection
Output against the department
Publications67bottom 18% of dept.847th of 1,033
this lab
most publishedleast published
Citations718bottom 3% of dept.1,001st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.