University of California-San Francisco · Microbiology & ImmunologyNoble Pathogenesis Lab
Suzanne M Noble · San Francisco, California
Research Focus
Dr. Suzanne Noble's research lab at UCSF focuses on understanding how certain fungi, particularly Candida species, colonize the human body without causing disease and how they can become pathogenic. The lab investigates the molecular mechanisms behind gut colonization by Candida albicans and skin colonization by Candida auris, helping to shed light on the transitions from harmless commensalism to pathogenicity. This research is crucial for developing strategies to manage fungal infections, especially those caused by drug-resistant strains.
Candida albicansCandida aurisgut microbiotaskin colonizationfungal pathogensimmune responsetranscription factorsvirulence mechanismspathogenesis
Research Aims
5AIM 01Identify genetic factors that regulate Candida albicans fitness during gut colonization.
AIM 02Characterize the immune response to Candida auris and its unique colonization strategies.
AIM 03Discover the molecular interactions between Candida species and host immune cells.
AIM 04Explore the transcription factors that modulate fungal behavior during colonization.
AIM 05Unravel the differences in immune responses triggered by Candida auris and Candida albicans.
Skills the Lab Values
PCRmouse modelscell culturetranscriptomic analysisgenomic editingbioinformaticsflow cytometrymolecular cloningimmunohistochemistry
Output against the department
Publications52bottom 12% of dept.426th of 486
this lab
most publishedleast published
Citations5.9kbottom 44% of dept.273rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.