University of Michigan-Ann Arbor · BiochemistryBrito Neurodegeneration Lab
Jailson Brito Querido · Ann Arbor, Michigan
Research Focus
Dr. Jailson Brito Querido's lab at the University of Michigan studies the role of a specific genetic mutation in two serious neurodegenerative diseases: Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Their work focuses on understanding how abnormal translation of RNA—specifically a repeat in the C9orf72 gene—leads to the formation of toxic proteins that damage neurons. By using advanced imaging and molecular techniques, they aim to uncover details of how this process happens and how it could be targeted for future therapies.
ALSFrontotemporal DementiaC9orf72RAN translationneurodegenerationcryoelectron microscopydipeptide repeat proteinsmRNA translationprotein aggregation
Research Aims
5AIM 01Investigate how the GGGGCC repeat interacts with the ribosome during translation.
AIM 02Identify protein factors that influence RAN translation in neurons.
AIM 03Determine the structural basis of repeat-associated non-AUG translation.
AIM 04Analyze the impact of toxic dipeptide repeat proteins on neuron function.
AIM 05Develop novel tools for studying neurodegenerative diseases related to abnormal mRNA translation.
Skills the Lab Values
cryoelectron microscopybiochemical assayscell culturegenetic manipulationprotein purificationmolecular cloningimmunofluorescenceRNA extractionWestern blottransfection
Output against the department
Publications25bottom 1% of dept.398th of 402
this lab
most publishedleast published
Citations909bottom 2% of dept.392nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.