Louisiana State University and Agricultural & Mechanical College · BiologyThe Nrf2 Defense Lab
Samithamby Jeyaseelan · Baton Rouge, Louisiana
Research Focus
Dr. Samithamby Jeyaseelan's lab focuses on understanding how pneumonia-derived sepsis affects the body, particularly its impact on organ function. By investigating the role of a protein called Nrf2 in immune responses, the lab aims to find new ways to enhance the body's defense against severe infections caused by antibiotic-resistant bacteria. Their work could lead to better treatments that reduce tissue damage and improve patient outcomes during pneumonia and sepsis.
Nrf2pneumoniasepsishost defenseoxidative stressKlebsiella pneumoniaeantibiotic resistanceorgan injuryimmune system
Research Aims
4AIM 01Investigate the effects of Nrf2 on survival and bacterial clearance during infection.
AIM 02Explore the role of Nrf2 in emergency granulopoiesis.
AIM 03Characterize the impact of Nrf2 ablation on alveolar macrophage function.
AIM 04Determine if enhancing Nrf2 signaling in the lungs can improve host defense against infections.
Skills the Lab Values
mouse modelscell cultureRNA extractionflow cytometryprotein assaysmolecular cloningimmunoblottinggene expression analysisphagocyte function assays
Output against the department
Publications123bottom 44% of dept.573rd of 1,033
this lab
most publishedleast published
Citations4.4kbottom 34% of dept.685th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.