The University of Texas Health Science Center at San Antonio · GeneticsUterine Fibroid Research Lab
Thomas G Boyer · San Antonio, Texas
Research Focus
Dr. Thomas G. Boyer's lab focuses on understanding uterine fibroids, which are non-cancerous tumors affecting women's health. The research investigates how specific molecular changes, particularly in RNA modifications, contribute to the formation and progression of these tumors. By studying these mechanisms, the lab aims to develop new therapeutic approaches to treat uterine fibroids more effectively.
uterine fibroidsm6A methylationepitranscriptometumor biologyepigenetic inhibitorsRNA sequencingmolecular pathologytherapeutic interventionmyometrial transformation
Research Aims
4AIM 01Profile the m6A modification landscape in uterine fibroids and adjacent tissues.
AIM 02Investigate the role of METTL3-dependent RNA methylation in fibrotic transformation.
AIM 03Assess the impact of m6A modifications on gene expression in uterine fibroids.
AIM 04Evaluate the therapeutic efficacy of epigenetic inhibitors in preclinical models of human uterine fibroids.
Skills the Lab Values
RNA sequencingmethylation profilingchromatin immunoprecipitation sequencing (ChIP-seq)cell culturein vivo mouse modelsgene expression analysisprotein expression analysis (Western blot)data analysis using bioinformaticstissue dissection and processing
Output against the department
Publications85bottom 25% of dept.194th of 259
this lab
most publishedleast published
Citations4.3kbottom 22% of dept.202nd of 259
this lab
most citedleast cited
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