Yale University · BiochemistryKe Lab
Ailong Ke · New Haven, Connecticut
Research Focus
Dr. Ailong Ke's lab at Yale University focuses on understanding the intricate roles of RNA in gene regulation and immunity using advanced techniques in biophysics and molecular genetics. The lab aims to develop new biotechnological applications, including RNA-based genome editing tools like CRISPR. By studying the structure and function of riboswitches, the research also seeks to identify new antibiotic targets relevant to human health.
RNA biologyCRISPRriboswitchesgenome editingbacterial physiology
Research Aims
4AIM 01Investigate the structure and mechanism of Type I CRISPR systems.
AIM 02Understand how CRISPR immunity is established by Cas1-Cas2 integrase.
AIM 03Develop genome editing applications based on CRISPR-Tn7 mechanisms.
AIM 04Identify ligands for orphan riboswitches to enhance antibiotic development.
Skills the Lab Values
CRISPRmolecular geneticsgenetic screeningbiochemical purificationRNA structure analysis
Output against the department
Publications109bottom 28% of dept.289th of 402
this lab
most publishedleast published
Citations4.5kbottom 25% of dept.301st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.