University of Kansas · PsychologyThe FXTAS Discovery Lab
Matthew W Mosconi · Lawrence, Kansas
Research Focus
Dr. Matthew W. Mosconi's lab focuses on understanding Fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder that affects motor skills, particularly in older adults. The lab strives to identify biomarkers and mechanisms that characterize disease progression in FXTAS, studying both genetic factors and brain changes over time. By comparing individuals with FXTAS to those without the syndrome, the research aims to provide insights that could lead to better tracking of the disease and potential treatments.
FXTASneurodegenerationbrain imagingcerebellar degenerationgenetic biomarkers
Research Aims
3AIM 01Establish new biobehavioral markers sensitive to disease progression in FXTAS.
AIM 02Define molecular and genetic risk mechanisms associated with brain and sensorimotor changes in FXTAS.
AIM 03Investigate changes in cerebellar volumes and microstructural integrity over time in FXTAS patients.
Skills the Lab Values
functional MRI (fMRI)diffusion magnetic resonance imaging (dMRI)motor behavior assessmentbiobehavioral markers developmentdata analysis in neuroimaging
Output against the department
Publications135bottom 45% of dept.160th of 296
this lab
most publishedleast published
Citations8.3ktop 36% of dept.106th of 296
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.