University of Texas Southwestern Medical Center · NeuroscienceTakahashi Lab
Joseph S Takahashi · Dallas, Texas
Research Focus
Dr. Joseph S. Takahashi's lab at UT Southwestern Medical Center focuses on understanding how the timing of food intake affects aging and lifespan. Their research explores the concept of caloric restriction and its interactions with circadian rhythms, studying how these factors can promote healthier aging. The lab's work seeks to uncover the molecular mechanisms behind these processes, particularly the role of inflammation and specific genes in regulating longevity.
caloric restrictioncircadian rhythmstime-restricted feedinglongevityinflammationgene expressionhealthspanaging mechanisms
Research Aims
5AIM 01Test whether time-restricted feeding alone can extend lifespan
AIM 02Investigate if enhancing Clock gene expression can improve health and longevity
AIM 03Examine the role of the cytokine Interleukin-1 beta in caloric restriction and lifespan
AIM 04Study the effects of caloric restriction on inflammation and metabolic health
AIM 05Disentangle the effects of calories, fasting, and eating patterns on longevity
Skills the Lab Values
mouse modelsgene expression analysisfeeding behavior studiesmetabolic assaysWestern blottingPCRRNA sequencingbioinformaticsexperimental designdata interpretation
Output against the department
Publications449top 13% of dept.87th of 671
this lab
most publishedleast published
Citations80ktop 3% of dept.19th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.