West Virginia University · NeuroscienceSchreurs Lab
Bernard G. Schreurs · Morgantown, West Virginia
Research Focus
Dr. Bernard G. Schreurs' lab investigates how sex differences influence Alzheimer's disease risk and treatment responses. The team leverages an innovative animal model using rabbits fed a high-cholesterol diet to explore the interactions between estrogen levels and cholesterol metabolism in relation to cognitive function. By examining how these factors contribute to the pathology of Alzheimer's disease, the lab aims to uncover mechanisms behind memory impairment and potential protective effects of estrogen.
Alzheimer's Diseasesex differencescholesterolestrogencognitive impairmentrabbit models
Research Aims
3AIM 01Investigate the effect of estrogen modulation on cognitive impairment in cholesterol-fed rabbits.
AIM 02Examine the role of 27-hydroxycholesterol in memory and cognitive function in a female rabbit model.
AIM 03Determine how estrogen receptor expression varies between male and female rabbits and its impact on Alzheimer's pathology.
Skills the Lab Values
behavioral assayselectrophysiologymolecular biology techniqueshistochemistryanimal handlingdiet manipulationdata analysisimmunohistochemistry
Output against the department
Publications136bottom 48% of dept.349th of 671
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.461st of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.