University of Michigan-Ann Arbor · BiochemistryThe Heme Haven
Stephen Wiley Ragsdale · Ann Arbor, Michigan
Research Focus
Dr. Stephen Wiley Ragsdale's lab focuses on understanding how specific proteins regulate critical processes related to heme and carbon monoxide in human health. Their research explores how these proteins protect against diseases related to oxidative stress, such as cardiovascular and neurological disorders, and investigates the mechanisms by which these proteins interact with metals and signaling molecules. This work has broad implications for both understanding human metabolism and developing new biotechnologies.
heme homeostasisredox regulationmetalloproteinsoxidative stresscellular protectioncarbon monoxideenzyme catalysis
Research Aims
5AIM 01Investigate the role of heme oxygenases in cellular protection against oxidative stress.
AIM 02Elucidate the mechanisms by which heme is trafficked and converted in cells.
AIM 03Explore the functions of Rev-Erb in linking circadian rhythms to metabolism.
AIM 04Characterize the interactions and dynamics of metalloproteins under varying redox conditions.
AIM 05Define the impact of cellular heme levels on metabolic regulation.
Skills the Lab Values
protein purificationcrystallographymass spectrometrycell culturefluorescence assaysspectroscopic techniquescomputational modelingenzyme kineticsco-immunoprecipitation
Output against the department
Publications256top 29% of dept.115th of 402
this lab
most publishedleast published
Citations18ktop 25% of dept.102nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.