Iowa State University · Biomedical EngineeringBarber Lab
Glen N. Barber · Ames, Iowa
Research Focus
Dr. Glen N. Barber's lab at Ohio State University studies how a protein called STING plays a key role in the immune system, particularly regarding how our bodies respond to infections and cancer. They focus on understanding the mechanisms by which STING signaling can make infected or damaged cells more recognizable to the immune system, potentially improving cancer treatment strategies. The lab's work has implications for developing more effective therapies for various health issues, including cancer and inflammatory diseases.
STINGinnate immunityphagocytosiscancer biologyimmune responseimmunotherapyDNA damageepigeneticstumor antigenscytosolic DNA
Research Aims
5AIM 01Evaluate how STING signaling enhances the immune recognition of infected or DNA-damaged cells.
AIM 02Investigate the epigenetic silencing of STING in aged cells.
AIM 03Characterize the genes activated by STING signaling that contribute to immune responses.
AIM 04Develop strategies to restore STING signaling in non-immunogenic cells.
AIM 05Explore the link between STING signaling and resistance to cancer therapies.
Skills the Lab Values
cell culturemolecular cloningflow cytometrymicroscopyRNA extractionWestern blotCRISPRgene expression analysisanimal modelsin vitro assays
Output against the department
Publications297top 31% of dept.186th of 595
this lab
most publishedleast published
Citations38ktop 6% of dept.34th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.