University of Texas Southwestern Medical Center · BiologyThe Metastasis Dynamics Lab
Srinivas Malladi · Dallas, Texas
Research Focus
Dr. Srinivas Malladi's lab focuses on understanding how certain types of breast cancer cells survive and metastasize to the brain. The research aims to uncover mechanisms that allow cancer cells to evade the immune system and resist therapy. By exploring the roles of specific proteins and immune interactions, the lab seeks to develop strategies that may enhance treatment responses and combat metastasis in breast cancer patients.
breast cancermetastasisNK cellsAXLHER2immune evasioncancer therapymetabolic resistance
Research Aims
5AIM 01Investigate how HER2+ breast cancer cells survive in the brain microenvironment.
AIM 02Characterize the properties of dormant breast cancer cells that lead to metastasis.
AIM 03Assess the role of AXL protein in mediating immune response dysfunction.
AIM 04Evaluate the effectiveness of AXL inhibitors on tumor cell survival in the brain.
AIM 05Develop preclinical models to study brain metastasis and therapeutic interventions.
Skills the Lab Values
cell cultureCRISPRimmunoprecipitationmass spectrometryChIP-seqin vivo modelstumor microenvironment analysisproteomicsflow cytometry
Output against the department
Publications94bottom 32% of dept.696th of 1,033
this lab
most publishedleast published
Citations3.7kbottom 28% of dept.745th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.