University of Pittsburgh-Pittsburgh Campus · EngineeringShoemaker Immunology Lab
Jason Edward Shoemaker · Pittsburgh, Pennsylvania
Research Focus
Dr. Jason Shoemaker's research focuses on understanding how the hormone estradiol affects immune responses during influenza infection, and how these effects differ between male and female biological subjects. His lab utilizes mathematical modeling and experimental methods to identify immune mechanisms influenced by estradiol. This research could lead to improved treatments tailored to individual hormonal levels and biological sex.
estradiolinfluenza infectionimmune responsemathematical modelingsex differenceshost factorsviral replicationgene expressionimmunologydrug targeting
Research Aims
3AIM 01Identify estradiol-regulated lung responses in influenza-infected male and female mice.
AIM 02Quantify viral load and gene expression in human respiratory cells pretreated with estradiol.
AIM 03Assess the role of monocytes in estradiol-regulated immune responses using knockout models.
Skills the Lab Values
mathematical modelingimmunological assaysgene expression analysismouse modelscell culture techniquesnetwork analysisRNA sequencingphospho-signalingpathway validation
Output against the department
Publications70bottom 13% of dept.243rd of 278
this lab
most publishedleast published
Citations1.5kbottom 10% of dept.249th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.