Yale University · BiochemistryNeural Circuitry and Behavior Lab
Michael R Koelle · New Haven, Connecticut
Research Focus
Dr. Michael Koelle's lab at Yale University focuses on understanding how brain circuits work by studying the egg-laying behavior in the tiny roundworm C. elegans. The lab aims to pinpoint how various signaling molecules like neurotransmitters and neuropeptides contribute to the activity of these circuits, which can provide insights into human brain diseases. By using advanced techniques such as imaging and genetics, the lab investigates the interactions of different neurons and how they govern behavior.
C. elegansneuromodulatorsneurotransmittersneuropeptidesneural circuitselectrophysiologyCa2+ imaginggenetic techniquesmechanosensory feedbacksignaling pathways
Research Aims
3AIM 01Investigate how Go antagonizes Gq signaling to regulate neuron and muscle activity.
AIM 02Define the remaining components of the egg-laying circuit and their connectivity.
AIM 03Study how mechanosensory feedback inhibits the circuit after eggs are laid.
Skills the Lab Values
GeneticsElectrophysiologyCa2+ imagingFluorescent Reporter ImagingElectron MicroscopyBiochemical AssaysData AnalysisOptogeneticsChemogeneticsBehavioral Analysis
Output against the department
Publications67bottom 12% of dept.352nd of 402
this lab
most publishedleast published
Citations4.4kbottom 25% of dept.302nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.