Cornell University · Microbiology & ImmunologyMcgeachy Immunology Lab
Mandy J Mcgeachy · Ithaca, New York
Research Focus
Dr. Mandy Mcgeachy's lab at Cornell University focuses on understanding how specific immune cells called Th17 cells can either protect the body from infections or contribute to autoimmune diseases like multiple sclerosis. The lab studies molecular mechanisms that influence Th17 cell behavior, especially a process called post-transcriptional regulation, which affects how these cells express key proteins involved in inflammation. By uncovering these pathways, the lab hopes to identify new therapeutic targets that can help manage autoimmune conditions.
Th17 cellspost-transcriptional regulationmultiple sclerosisimmune responseautoimmunity
Research Aims
3AIM 01Investigate how the PIP5K1a-ARS2 interaction is regulated in differentiating Th17 cells
AIM 02Explore how the PIP5K1a-ARS2 axis regulates Th17 protein expression
AIM 03Determine the therapeutic potential of targeting PIP5K1a and ARS2 in inflammatory Th17 responses in vivo.
Skills the Lab Values
cell cultureRNA immunoprecipitation sequencingflow cytometrymouse modelsWestern blotprotein expression analysisCRISPRmolecular cloning
Output against the department
Publications89bottom 30% of dept.341st of 486
this lab
most publishedleast published
Citations12ktop 31% of dept.152nd of 486
this lab
most citedleast cited
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