Tulane University of Louisiana · Microbiology & ImmunologyMclachlan Lab
James B Mclachlan · New Orleans, Louisiana
Research Focus
Dr. James B. Mclachlan's lab at Tulane University focuses on improving vaccine design to better protect against infections that enter the body through mucosal surfaces, such as the lungs and gastrointestinal tract. The lab investigates how different adjuvants can enhance immune responses in these areas, leading to better protection against diseases caused by bacteria and viruses. By exploring the mechanisms of immune response, the lab aims to develop more effective vaccines that induce both cellular and humoral immunity in mucosal tissues.
vaccine designmucosal immunityadjuvantshumoral immunitycellular immunitybacterial infectionsviral infectionsimmunizationT cellsB cells
Research Aims
5AIM 01Identify how intradermal immunization with dmLT combined with OMVs affects T cell migration to mucosal tissues.
AIM 02Evaluate the impact of adjuvant combinations on the generation of mucosal B cell responses.
AIM 03Investigate whether T cells and B cells from immunization become tissue resident memory cells.
AIM 04Assess the protective efficacy of dmLT-OMV-adjuvanted vaccines against mucosal infections.
AIM 05Explore mechanisms by which adjuvants regulate immune responses at mucosal sites.
Skills the Lab Values
intradermal immunizationflow cytometrycell culturevaccine formulationimmunological assaysanimal modelsantibody quantificationdata analysisWestern blottingPCR
Output against the department
Publications99bottom 34% of dept.315th of 486
this lab
most publishedleast published
Citations3.3kbottom 24% of dept.370th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.