Ohio State University-Main Campus · NeuroscienceObrietan Chronobiology Lab
Karl H Obrietan · Columbus, Ohio
Research Focus
Dr. Karl H. Obrietan's lab focuses on understanding how circadian rhythms affect brain functions, particularly in areas related to mood, memory, and decision-making. They investigate how the brain's internal clock interacts with different brain circuits and how disruptions in this timing can lead to neurological disorders. By using innovative techniques, including advanced imaging and genetic models, the lab aims to uncover the biological mechanisms behind these processes and their implications for treatment.
circadian rhythmscognitionmemory formationneurophysiologybehavioral sciencetransgenic modelscellular imagingmood disorders
Research Aims
3AIM 01Examine the core clock transcriptional feedback loop within cortico-limbic circuits.
AIM 02Investigate clock timing and entrainment mechanisms using 2-photon imaging.
AIM 03Assess how circadian clock timing influences memory formation and neuronal plasticity.
Skills the Lab Values
2-photon imagingmouse modelscell cultureAAV-based genetic methodsgenetic interrogationlongitudinal cellular profilingbehavioral assaysmolecular biology techniquesCREB signaling analysis
Output against the department
Publications125bottom 44% of dept.370th of 671
this lab
most publishedleast published
Citations12ktop 33% of dept.224th of 671
this lab
most citedleast cited
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