UWMUniversity of Wisconsin-Madison · Neuroscience
Chapman Lab
Edwin R Chapman · Madison, Wisconsin
Research Focus
Dr. Edwin R. Chapman's lab at the University of Wisconsin-Madison studies the molecular mechanics of membrane fusion in neurons, focusing on the release of neurotransmitters. The team utilizes innovative techniques to analyze the dynamics and structure of fusion pores, which are crucial for synaptic transmission. Their research aims to answer key questions about how neurons communicate and the potential implications for treating mental disorders.
membrane fusionsynaptic vesiclesneurotransmitter releasefusion poresSNARE proteinscryogenic electron microscopyexocytosisneural communicationbiophysicsnanostructures
Research Aims
5AIM 01Investigate the dynamics of SNARE complexes and fusion pores during neurotransmitter release.
AIM 02Determine the structural framework of fusion pores using cryogenic electron microscopy.
AIM 03Examine the conditions under which synaptic vesicles undergo full fusion collapse versus kiss-and-run exocytosis.
AIM 04Explore how accessory proteins regulate the formation and dynamics of fusion pores.
AIM 05Develop optical techniques to measure fusion pore size during synaptic transmission.
Skills the Lab Values
electrophysiologycryogenic electron microscopysingle particle analysisnanodisk systemsimaging techniquesquantitative analysisbiophysical measurementsoptical methods
Output against the department
Publications296top 23% of dept.153rd of 671
this lab
most publishedleast published
Citations22ktop 19% of dept.127th of 671
this lab
most citedleast cited
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