Harvard University · BiologyCortical Interneuron Development Lab
Gordon J Fishell · Cambridge, Massachusetts
Research Focus
Dr. Gordon J. Fishell's lab at Harvard Medical School focuses on understanding the development of cortical interneurons, specifically those expressing somatostatin (SST) and parvalbumin (PV). They aim to unravel how diverse these interneurons are and how genetic regulation and signals from neighboring cells shape their development and function, contributing to circuit formation in the brain. This research holds significance for understanding how disruptions in these processes can lead to brain diseases.
cortical interneuronsdevelopmental geneticsgene regulatory networkssynaptic connectivitybrain diseasessomatostatinparvalbumintranscription factorscircuit formationmental illness
Research Aims
3AIM 01Investigate how transcription factors influence cortical interneuron development.
AIM 02Examine the diversity of SST-expressing interneurons in cortical circuits.
AIM 03Identify the molecular and cellular mechanisms behind cortical interneuron diversity.
Skills the Lab Values
molecular biologygene expression analysistranscriptome sequencingoptogeneticscell culturemouse modelsin situ hybridizationimmunohistochemistrygenetic engineeringcomputer programming
Output against the department
Publications333top 15% of dept.157th of 1,033
this lab
most publishedleast published
Citations35ktop 9% of dept.90th of 1,033
this lab
most citedleast cited
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