The University of Texas Health Science Center at San Antonio · BiochemistryGenome Repair Initiative
Shaun Olsen · San Antonio, Texas
Research Focus
Dr. Shaun Olsen's lab focuses on understanding how specific proteins called RAD51 paralogs help repair damaged DNA in cells. Their research is crucial for maintaining genome integrity, and they explore how failures in this repair process can lead to cancer. By studying these complex protein interactions, they aim to develop new cancer therapies targeting DNA repair pathways.
RAD51tumor suppressorDNA repaircancer therapygenome integrityhomologous recombinationbreast cancerovarian cancerprotein complexes
Research Aims
4AIM 01Determine the structural basis of how CX3 promotes RAD51-ssDNA nucleoprotein filament assembly.
AIM 02Investigate the role of BCDX2 in RAD51 filament assembly and its implications for cancer.
AIM 03Elucidate how RAD51 paralog complexes interact with partner proteins to mediate DNA repair.
AIM 04Understand the consequences of dysregulation of RAD51 paralogs in cancer development.
Skills the Lab Values
cryo-Electron Microscopysingle molecule assaysbiochemical analysisbiophysical analysiscell-based assaysmolecular biology techniquesprotein purificationDNA manipulation
Output against the department
Publications85bottom 18% of dept.326th of 402
this lab
most publishedleast published
Citations6.2kbottom 35% of dept.260th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.