Vanderbilt University · PhysiologyThe Islet Dynamics Lab
David Aaron Jacobson · Nashville, Tennessee
Research Focus
David Aaron Jacobson's lab at Vanderbilt University explores the mechanisms behind insulin and glucagon secretion from pancreatic islet cells, particularly in the context of type 2 diabetes. The research focuses on how certain proteins regulate calcium levels within the cells, affecting hormone secretion and contributing to diabetes complications. By understanding these processes, the lab aims to identify new therapeutic targets to improve glucose homeostasis and reduce the health burden from diabetes.
beta celltype 2 diabetesinsulin secretioncalcium handlingislet functionNa+/K+-ATPasecalcium extrusionGPCR signalingPMCA1NCX1
Research Aims
4AIM 01Determine the mechanisms regulating Na+/K+-ATPase control of beta-cell function in health and diabetes.
AIM 02Elucidate how PMCA1 and NCX1 regulate beta-cell calcium extrusion and hormone secretion.
AIM 03Investigate the impact of diabetic conditions on islet cell calcium handling and hormone secretion.
AIM 04Assess how alterations in cell calcium handling contribute to beta-cell dysfunction.
Skills the Lab Values
cell culturetransgenic mouse modelsmolecular biology techniquesCRISPR/Cas9electrophysiologyfluorescence microscopyWestern blottingRNA interferencebiochemistrydata analysis
Output against the department
Publications139bottom 45% of dept.155th of 286
this lab
most publishedleast published
Citations3.6kbottom 29% of dept.203rd of 286
this lab
most citedleast cited
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