University of Missouri-Columbia · Microbiology & ImmunologyAptamer Innovations Lab
Margaret J Lange · Columbia, Missouri
Research Focus
Dr. Margaret J Lange's lab at the University of Missouri-Columbia focuses on understanding the HIV virus, specifically its capsid protein and its interactions with host cells. Using innovative tools called aptamers—molecular constructs that can bind to specific targets—the lab aims to explore the structure and dynamics of the HIV capsid during replication. Their work seeks to develop new diagnostic technologies and therapeutic targets that can ultimately improve strategies for managing HIV infections.
HIVcapsid proteinaptamersbiosensorsviral assemblytargeted therapydrug designviral interactionsHIV replication
Research Aims
5AIM 01Develop aptamers that bind specific structural forms of the HIV capsid protein.
AIM 02Create interaction maps defining how aptamers affect HIV capsid dynamics.
AIM 03Investigate the biological significance of aptamer-capsid interactions.
AIM 04Design biosensor technologies for detecting HIV capsid forms in cells.
AIM 05Advance therapeutic strategies targeting HIV interactions.
Skills the Lab Values
aptamer developmentmolecular cloningaffinity chromatographycell culture techniquesPCRRNA manipulationbiochemical assaysprotein purificationhigh-throughput screening
Output against the department
Publications49bottom 11% of dept.432nd of 486
this lab
most publishedleast published
Citations516bottom 4% of dept.468th of 486
this lab
most citedleast cited
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