University of Delaware · BiologyEphrin Signaling and Cell Adhesion Lab
Shuo Wei · Newark, Delaware
Research Focus
Dr. Shuo Wei's lab at the University of Delaware focuses on understanding how specific proteins called ephrins and their receptors interact and influence cell signaling and adhesion. This research is important because disruptions in these interactions can lead to serious health issues, including developmental and neurological disorders. The lab aims to investigate how these proteins are processed by enzymes and to explore their role in cell communication, which could help identify new therapeutic strategies for related diseases.
ephrinscell adhesionsignaling pathwaysproteolysisneurological disorderstumorsdevelopmental defectsADAM proteinsbeta-catenincell communication
Research Aims
4AIM 01Investigate the mechanisms of ephrinB shedding by ADAM proteases.
AIM 02Determine the effects of ephrinB shedding on cell signaling and adhesion.
AIM 03Explore the relationship between ADAM-ephrinB interactions and beta-catenin signaling.
AIM 04Assess the physiological impact of ephrinB processing in neuronal functions.
Skills the Lab Values
cell cultureWestern blotgene editing (mutagenesis)biochemical assaysmouse modelsimmunofluorescence microscopyprotein purificationsignal transduction analysisRNA extraction and analysis
Output against the department
Publications919top 2% of dept.21st of 1,033
this lab
most publishedleast published
Citations72ktop 2% of dept.20th of 1,033
this lab
most citedleast cited
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