AECAlbert Einstein College of Medicine · Genetics
Cardiac Development and Genomics Lab
Bernice E Morrow · Bronx, New York
Research Focus
Dr. Bernice Morrow's lab at the Albert Einstein College of Medicine focuses on understanding how specific genes influence the development of the heart, particularly in relation to congenital heart diseases linked to a genetic condition known as 22q11.2 deletion syndrome. They use advanced techniques to study molecular mechanisms in developing mouse models, aiming to uncover how cell fate decisions are made during heart formation. By identifying and manipulating genetic pathways, the lab seeks to provide insights that could help in treating heart defects associated with this condition.
Tbx1congenital heart disease22q11.2 deletion syndromecardiac developmentmouse modelsgene expressionsingle-cell RNA sequencingcell fate determinationembryonic development
Research Aims
3AIM 01Investigate the role of Tbx1 in multilineage primed progenitors during heart formation.
AIM 02Explore the specific functions of Tbx1 in the anterior and lateral parts of the cardiac lineage.
AIM 03Examine distant-acting enhancers and their role in Tbx1 function through genetic modifications.
Skills the Lab Values
single cell RNA sequencingmouse geneticsspatial transcriptomicsmolecular cloningembryo manipulation techniquesgenetic engineering (knock-in and knock-out)flow cytometrycell culturedata analysis using bioinformatics
Output against the department
Publications344top 23% of dept.60th of 259
this lab
most publishedleast published
Citations17ktop 35% of dept.91st of 259
this lab
most citedleast cited
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