University of California-San Diego · BiologyGoldrath Immunology Lab
Ananda W Goldrath · La Jolla, California
Research Focus
Dr. Ananda W Goldrath's lab at UC San Diego focuses on understanding how T cells, especially memory CD8 T cells, adapt to different tissues in the body to provide effective immunity against infections and cancers. The lab investigates the unique changes in gene expression and metabolism that allow these immune cells to survive and function in various environments, particularly in the small intestine. This research has implications for developing better vaccines and immunotherapies tailored to enhance the immune response in specific tissues.
T cell memoryimmune responsetissue residencyCD8 T cellsmetabolic adaptationsimmunotherapyvaccinestranscriptional regulationimmunopathology
Research Aims
3AIM 01Define the role of Hic1 in the regulation of tissue-resident memory T cell differentiation and maintenance.
AIM 02Elucidate the role of Srebp2 in the transcriptional network governing tissue-resident memory T cells.
AIM 03Determine how tissue-specific factors regulate the fate and function of memory CD8 T cells.
Skills the Lab Values
cell culturemouse modelsflow cytometryRNA sequencinggene expression analysisWestern blottingtranscriptional profilingmetabolic assaysimmunohistochemistry
Output against the department
Publications257top 23% of dept.240th of 1,033
this lab
most publishedleast published
Citations26ktop 14% of dept.147th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.