RURush University · Microbiology & Immunology
HIV Neuroinflammation Research Lab
Joao Filipe Inacio Mamede · Chicago, Illinois
Research Focus
Dr. Joao Filipe Inacio Mamede's lab studies HIV and its effects on the brain, particularly focusing on how HIV and substance abuse, like Methamphetamine, trigger neuroinflammation and cognitive disorders. They explore the cellular interactions and molecular pathways involved in these processes, aiming to uncover new therapeutic targets to improve the health of individuals living with HIV/AIDS. Through advanced techniques, the lab seeks to better understand brain responses in people who experience these conditions despite current treatments.
HIVneuroinflammationneurocognitive disordersMethamphetamineinnate immunity
Research Aims
5AIM 01Identify the molecular mechanisms triggering innate immunity activation in brain cells affected by HIV and Meth.
AIM 02Characterize the crosstalk between HIV-infected and non-infected brain cells under treatment conditions.
AIM 03Determine the biological consequences of HIV and Meth-induced innate immunity activation.
AIM 04Assess the impact of cART on HIV cytoplasmic trafficking and innate immune sensing.
AIM 05Explore therapeutic potential of cGAS/STING antagonists in reducing chronic neuroinflammation.
Skills the Lab Values
cell culturePCRimmunofluorescencesuper-resolution microscopyRNA sequencingcytokine profilingmachine learninggene expression analysisanimal modelsorganoid culture
Output against the department
Publications1bottom 1% of dept.480th of 486
this lab
most publishedleast published
Citations0bottom 1% of dept.479th of 486
this lab
most citedleast cited
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