Temple University · ChemistryHIV Drug Resistance Dynamics Lab
Ronald Levy · Philadelphia, Pennsylvania
Research Focus
Dr. Ronald Levy's lab focuses on understanding how HIV (Human Immunodeficiency Virus) evolves and becomes resistant to treatment. The research combines advanced computational methods with experimental studies to predict how the virus changes in response to drugs. By studying the interactions between viral proteins and treatment medications, the lab aims to develop new tools for predicting drug resistance, which could ultimately help in designing more effective therapies for HIV patients.
HIVdrug resistancemolecular dynamicsbiophysicsmachine learningviral proteinsantiviral therapiesprotein structuresequence co-variation
Research Aims
3AIM 01Develop computational tools to forecast HIV evolutionary trajectories under drug selection pressure.
AIM 02Analyze the effects of protein mutations using advanced sampling methods in molecular dynamics.
AIM 03Determine the molecular basis for binding modes of HIV inhibitors and their solvation effects.
Skills the Lab Values
molecular dynamics simulationshigh-resolution cryo-EMprotein-protein interaction analysisbiophysical techniquesdrug binding assaysdata modelingcomputational biologyPython programmingvirology techniques
Output against the department
Publications956top 5% of dept.10th of 216
this lab
most publishedleast published
Citations72ktop 3% of dept.6th of 216
this lab
most citedleast cited
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