University of Minnesota-Twin Cities · BiochemistryViral Dynamics and Gene Therapy Unit
Hideki Aihara · Minneapolis, Minnesota
Research Focus
Dr. Hideki Aihara's lab at the University of Minnesota focuses on understanding how viruses replicate and invade host cells. By studying the molecular structures of various viruses, including retroviruses like the Human T-cell Leukemia virus and coronaviruses, the lab aims to uncover mechanisms that could lead to new antiviral treatments. The research also explores gene delivery methods, which can be helpful in both therapy and research applications.
viral replicationhost cell invasionretroviral integrationcoronavirusexoribonucleaseantibodiesgene therapyantiviral strategiesstructural biology
Research Aims
5AIM 01Investigate the mechanisms of retroviral integration into host chromosomes.
AIM 02Explore the replication of coronavirus RNA genomes.
AIM 03Characterize how exoribonuclease complexes facilitate viral genome replication.
AIM 04Evaluate receptor binding inhibition of the coronavirus spike protein.
AIM 05Develop antiviral strategies and gene delivery tools.
Skills the Lab Values
structural biology techniquescell cultureRNA extraction and analysisantibody developmentmolecular cloningviral infection assaysprotein purificationgenome sequencingsmall molecule screening
Output against the department
Publications233top 33% of dept.128th of 402
this lab
most publishedleast published
Citations8.3kbottom 44% of dept.224th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.