Oregon Health & Science University · PhysiologyThe RuvBL1 Initiative
Xiangshu Xiao · Portland, Oregon
Research Focus
Dr. Xiangshu Xiao's lab at Oregon Health & Science University focuses on developing new drugs for triple negative breast cancer (TNBC), which is a particularly aggressive subtype of breast cancer. The lab is working on small molecules that can inhibit the RuvBL1/L2 complex, which is important for repairing DNA damage in cancer cells. This research aims to create therapies that selectively target cancer cells without harming healthy cells, improving treatment options for patients with this challenging disease.
triple negative breast cancerDNA repairsmall molecule inhibitorsRuvBL1/L2 complexcancer therapeutics
Research Aims
3AIM 01Study the mechanism of action of the novel lead compound.
AIM 02Optimize the lead compound using medicinal chemistry strategies.
AIM 03Investigate the anti-TNBC efficacy of optimized compounds in preclinical models.
Skills the Lab Values
cell culturein vitro assaysmedicinal chemistry techniquespreclinical modelsdrug efficacy testing
Output against the department
Publications93bottom 25% of dept.215th of 286
this lab
most publishedleast published
Citations2.7kbottom 20% of dept.229th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.