Massachusetts Institute of Technology · ChemistryRaines Protein Lab
Ronald T Raines · Cambridge, Massachusetts
Research Focus
Professor Ronald T. Raines' lab at MIT focuses on innovating protein chemistry to improve drug delivery methods. The research aims to develop new techniques for proteins to cross cellular membranes and target intracellular processes, which can lead to new therapies for serious diseases, including cancer. By modifying proteins chemically, the lab explores their potential therapeutic applications and how they can be harnessed effectively in biomedical research.
protein chemistrydrug deliverychemical biologyesterificationcellular uptaketumor suppressiongene editingbiomedical researchenzymology
Research Aims
5AIM 01Investigate the cellular uptake mechanisms of esterified proteins.
AIM 02Explore the enzymatic hydrolysis of esterified proteins by cellular esterases.
AIM 03Develop methods for targeting proteins to act on intracellular processes.
AIM 04Assess the application of esterification for enhancing cytotoxicity in cancer therapy.
AIM 05Generalize the use of this approach for anchoring therapeutic oligonucleotides on cell surfaces.
Skills the Lab Values
protein purificationesterification techniquescell culturefluorescence microscopyin vitro assaysprotein characterizationenzyme kineticsRNA oligonucleotide manipulationCRISPR technology
Output against the department
Publications674top 9% of dept.19th of 216
this lab
most publishedleast published
Citations41ktop 9% of dept.20th of 216
this lab
most citedleast cited
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