UWMUniversity of Wisconsin-Madison · Biochemistry
Bicaudal-C Regulation Unit
Michael D Sheets · Madison, Wisconsin
Research Focus
Dr. Michael D. Sheets' lab at the University of Wisconsin-Madison studies how specific proteins control gene expression during development, focusing on a protein called Bicaudal-C. This protein is crucial for making cell fate decisions that guide the normal development of vertebrates, including humans. The lab employs innovative techniques to unravel Bicaudal-C's role in regulating mRNA translation, which may lead to better understanding of diseases linked to cell dysfunction.
mRNA regulationBicaudal-Cvertebrate developmenttranslational controlcell fate specification
Research Aims
3AIM 01Define how Bicaudal-C selects its target mRNAs
AIM 02Investigate how Bicaudal-C represses translation
AIM 03Explore Bicaudal-C's role in early cell-fate specification in Xenopus
Skills the Lab Values
RNA-protein biochemistrymolecular geneticsXenopus embryo manipulationreporter assay developmentbiochemical assays
Output against the department
Publications112bottom 28% of dept.287th of 402
this lab
most publishedleast published
Citations3.6kbottom 18% of dept.328th of 402
this lab
most citedleast cited
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