University of North Carolina at Chapel Hill · BiochemistryDNA Repair and Cancer Therapeutics Unit
Dale A Ramsden · Chapel Hill, North Carolina
Research Focus
Dr. Dale Ramsden's lab at the University of North Carolina focuses on understanding how DNA polymerase theta contributes to genome stability and its role in cancer. Using a multidisciplinary approach, the lab looks into the mechanisms of DNA damage repair, particularly in BRCA-deficient cancers, and seeks to identify ways to selectively target these vulnerabilities to develop more effective cancer therapies. Their research combines molecular biology with structural biology and biophysics to inform clinical applications.
DNA RepairCancer TherapyMolecular BiologyBRCA MutationsPolymerase Theta
Research Aims
3AIM 01Determine molecular requirements for polymerase theta-dependent repair.
AIM 02Identify cancer-relevant contexts that engage DNA polymerase theta.
AIM 03Develop new strategies for targeting polymerase theta-dependent repair in cancer.
Skills the Lab Values
Molecular CloningIn Vitro AssaysCell Culture TechniquesProtein PurificationBiochemical Assays
Output against the department
Publications196top 43% of dept.170th of 402
this lab
most publishedleast published
Citations10ktop 48% of dept.194th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.