RUThe Rockefeller University · Genetics
Cao Neurogenesis Lab
Junyue Cao · New York, New York
Research Focus
Dr. Junyue Cao's research lab at Rockefeller University is focused on understanding how neurogenesis, or the generation of new neurons, changes in the aging brain and in conditions such as Alzheimer's disease. The lab employs advanced genomic techniques to investigate the complexities of these processes at the single-cell level, aiming to uncover potential therapeutic strategies to restore normal brain function. Through innovative high-throughput methodologies, the lab seeks to visualize and characterize the molecular dynamics of neuronal growth and differentiation across various conditions.
neurogenesisAlzheimer's diseasesingle-cell genomicstemporal-spatial dynamicsmolecular heterogeneityhigh-throughput techniquescellular differentiationbrain homeostasisagingtranscriptomics
Research Aims
5AIM 01Develop high-throughput low-cost single-cell genomics methods to study neurogenesis
AIM 02Profile molecular heterogeneity in human brains affected by aging and Alzheimer's disease
AIM 03Identify cellular differentiation trajectories in mouse models of neurogenesis
AIM 04Investigate the role of environmental factors in regulating neurogenesis
AIM 05Characterize transcriptomic features associated with impaired neurogenesis.
Skills the Lab Values
single-cell RNA sequencingspatial transcriptomicsbioinformaticscell culturemouse modelsdata analysismolecular profilingneuron differentiationhigh-throughput screeningtranscriptome analysis
Output against the department
Publications93bottom 28% of dept.185th of 259
this lab
most publishedleast published
Citations11ktop 46% of dept.118th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.