Vanderbilt University · EngineeringThe RNA Delivery Dynamics Lab
Ethan Lippmann · Nashville, Tennessee
Research Focus
Dr. Ethan Lippmann's lab focuses on developing innovative delivery methods for RNA-based therapies to treat conditions like Alzheimer's disease. Their work centers on using specially designed lipid conjugates to enhance the targeting of specific cells in the brain, allowing for effective silencing of genes associated with the disease. By studying how these substances interact within the brain's structure, the lab aims to improve therapeutic outcomes for patients.
RNA therapeuticsAlzheimer's diseasegene silencinglipid conjugatesmyeloid cellsdrug deliveryperivascular transportmicrogliamacrophages
Research Aims
3AIM 01Evaluate siRNA-EG18's effectiveness in silencing CD33 in brain myeloid cells.
AIM 02Analyze the impact of aging and amyloidosis on siRNA-EG18 targeting.
AIM 03Benchmark siRNA-EG18 against existing lipid-siRNA conjugates in clinical trials.
Skills the Lab Values
siRNA design and synthesislipid modification techniquescell cultureflow cytometrysingle-cell RNA sequencinganimal models of diseasedrug formulationmicroscopybioinformatics
Output against the department
Publications125bottom 28% of dept.197th of 278
this lab
most publishedleast published
Citations4.3kbottom 33% of dept.187th of 278
this lab
most citedleast cited
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