University of Missouri-Columbia · Biomedical EngineeringLin Microbiome Lab
Ai-Ling Lin · Columbia, Missouri
Research Focus
Dr. Ai-Ling Lin's lab focuses on understanding how the gut microbiome influences brain health, especially in the context of Alzheimer's disease. The research aims to determine how imbalances in gut bacteria are linked to brain changes and cognitive decline, using advanced imaging techniques and animal models. By exploring dietary interventions and the role of specific biological pathways, the lab hopes to uncover new ways to mitigate the effects of Alzheimer's disease.
Alzheimer's Diseasegut-brain axismicrobiome7T MRIneuroinflammationcognitive impairmentpreclinical modelsdietary interventionfecal microbiome transplantation
Research Aims
3AIM 01Identify the correlation between gut dysbiosis and Alzheimer's disease imaging markers in humans.
AIM 02Investigate the impact of iNOS inhibition on neuroinflammation related to dysbiosis.
AIM 03Assess the effects of inulin supplementation on cognitive function and microbiome balance.
Skills the Lab Values
7T MRI imagingmicrobiome sequencingcognitive testinganimal modelsfecal microbiome transplantationbiochemical assaystranscriptomicsWestern blotcell culture
Output against the department
Publications32bottom 2% of dept.581st of 595
this lab
most publishedleast published
Citations2.3kbottom 17% of dept.492nd of 595
this lab
most citedleast cited
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