University of California-Irvine · PhysiologyPotassium Channel Research Lab
Geoffrey W Abbott · Irvine, California
Research Focus
Dr. Geoffrey Abbott's lab at UC Irvine focuses on understanding how certain small molecules can influence potassium channels in the brain. These channels are important for neuron function and play a role in conditions like epilepsy and addiction. By studying compounds derived from plants, the team aims to develop new treatments for these serious health issues. Their research combines advanced simulations, mutagenesis techniques, and mouse model testing to discover how these compounds work and how they can help in therapy.
potassium channelsepilepsyaddictionsmall moleculesdrug development
Research Aims
3AIM 01Investigate how the diterpene carnosic acid opens specific potassium channels in neurons.
AIM 02Examine the molecular action of gallic acid on other potassium channels linked to ataxia and epilepsy.
AIM 03Test the therapeutic effects of various compounds on mouse models of neurological disorders.
Skills the Lab Values
molecular dynamics simulationselectrophysiologysite-directed mutagenesisin vivo testingmouse models
Output against the department
Publications216top 29% of dept.84th of 286
this lab
most publishedleast published
Citations8.6ktop 38% of dept.110th of 286
this lab
most citedleast cited
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