University of Minnesota-Twin Cities · BiologyJameson Lab
Stephen C Jameson · Minneapolis, Minnesota
Research Focus
Dr. Stephen C. Jameson's lab at the University of Minnesota focuses on understanding how aging affects the immune system, particularly the role of senescent cells in reducing the body's ability to respond to infections like COVID-19. The lab explores how these senescent cells can create a hostile environment for immune responses and investigates potential therapies to eliminate them. Additionally, the lab studies how certain CD8+ T cells can lose function without being deleted, which is crucial for preventing autoimmune diseases.
agingimmune responsesenescent cellspathogen controlCD8+ T cell toleranceautoimmune diseaseimmunosenescencecytokine stormtherapeutic strategies
Research Aims
5AIM 01Investigate the impact of senescent cells on immune dysfunction in aged organisms.
AIM 02Explore therapeutic strategies for eliminating senescent cells to restore immune function.
AIM 03Study the mechanisms of non-deletional tolerance in CD8+ T cells.
AIM 04Analyze the TCR repertoire in relation to autoimmune disease risks.
AIM 05Define the effects of aging on immune system responses to pathogens.
Skills the Lab Values
cell culturemouse modelsRNA sequencingsingle cell genomicsflow cytometryTCR sequencingbioinformaticsin vivo imagingimmunohistochemistry
Output against the department
Publications320top 17% of dept.171st of 1,033
this lab
most publishedleast published
Citations32ktop 10% of dept.105th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.