Boston University · BiochemistryGlycoVax Lab
Joseph Zaia · Boston, Massachusetts
Research Focus
Dr. Joseph Zaia's lab focuses on improving influenza vaccines by studying how the virus's surface proteins, specifically hemagglutinin (HA), are modified with sugars (glycosylation). By understanding the relationship between these sugar modifications and the immune response they provoke, the team aims to design better vaccines that can be more effective against the ever-evolving virus. This research could lead to the development of a universal vaccine that protects against various strains of the virus.
influenzavaccine designglycosylationhemagglutininimmunogenicityglycoproteomicsantigenic variationmass spectrometryrecombinant vaccines
Research Aims
5AIM 01Investigate the role of glycosylation in the immune response to influenza viruses.
AIM 02Identify glycosylation patterns that enhance vaccine efficacy.
AIM 03Develop strategies for designing recombinant vaccines with optimal HA glycosylation.
AIM 04Utilize mass spectrometry to analyze glycosite variations.
AIM 05Create predictive models for glycoprotein immunogenicity based on HA structures.
Skills the Lab Values
mass spectrometryglycoproteomicsmolecular modelingantigenic cartographycomputational modelingcell cultureimmunoassaysdata analysis in bioinformaticsPCR
Output against the department
Publications251top 29% of dept.118th of 402
this lab
most publishedleast published
Citations10ktop 47% of dept.189th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.