Washington University in St Louis · NeuroscienceInclusion Body Myopathy Research Lab
Conrad C Weihl · Saint Louis, Missouri
Research Focus
Dr. Conrad C. Weihl's lab focuses on understanding the mechanisms behind inclusion body myopathy, a serious muscle disease. The research investigates how protein aggregates might spread between muscle fibers and cause degeneration, with potential applications for new therapies. By studying muscle tissues affected by this disease, the lab aims to clarify the links between different types of protein abnormalities and develop strategies to interrupt their harmful spread.
protein aggregationinclusion body myopathymuscle degenerationlysosomal dysfunctionTDP-43
Research Aims
4AIM 01Explore the prion-like mechanisms of protein spread in muscle diseases.
AIM 02Confirm TDP-43 aggregates can induce further aggregation in muscle fibers.
AIM 03Demonstrate how these aggregates lead to lysosomal dysfunction.
AIM 04Evaluate the pathway of protein aggregate spread from one muscle fiber to another.
Skills the Lab Values
cell culturemouse modelsCoculture Techniquesfluorescence microscopyCRISPR screening
Output against the department
Publications23bottom 4% of dept.646th of 671
this lab
most publishedleast published
Citations15ktop 27% of dept.181st of 671
this lab
most citedleast cited
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