Georgia State University · BiologyShi Lab
Hang Shi · Atlanta, Georgia
Research Focus
Dr. Hang Shi's lab at Georgia State University focuses on understanding how an enzyme called HDAC1 affects liver health and diseases, specifically non-alcoholic fatty liver disease (NAFLD), which is linked to obesity and diabetes. The research investigates how HDAC1 contributes to fat buildup and inflammation in the liver, potentially leading to severe liver complications. By exploring the relationship between diet and epigenetic changes in the liver, the lab aims to identify new therapeutic strategies for treating NAFLD.
HDAC1non-alcoholic fatty liver disease (NAFLD)epigeneticsliver inflammationobesitynutrient sensingfatty livermetabolic disorderstranscription regulation
Research Aims
3AIM 01Investigate the role of HDAC1 in promoting fat buildup in the liver.
AIM 02Examine how HDAC1 influences liver inflammation and the development of NASH.
AIM 03Determine the mechanisms by which HDAC1 is regulated by excess nutrients.
Skills the Lab Values
gene expression analysismouse modelsnutrient manipulationepigenetic profilingcell culturehistone modification techniquesPCRWestern blottingbioinformatics analysis
Output against the department
Publications137bottom 49% of dept.519th of 1,033
this lab
most publishedleast published
Citations12ktop 30% of dept.309th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.