Thomas Jefferson University · BiologyMitochondrial Metabolism and Adaptation Lab
Erin Seifert · Philadelphia, Pennsylvania
Research Focus
Dr. Erin Seifert's lab studies how fatty acids are processed by the body when mitochondrial function is impaired, specifically in conditions like mitochondrial myopathy. This research focuses on understanding how skeletal muscle, liver, and heart adapt to these deficiencies to manage energy production and cellular stress. Their ultimate goal is to identify new ways to support metabolic health in individuals with mitochondrial diseases.
mitochondrial dysfunctionfatty acid metabolismskeletal muscleinsulin signalingadaptationglucose uptakecellular stressliverheartmetabolic compensation
Research Aims
3AIM 01Investigate how fatty acid substrates are processed in organs when oxidative phosphorylation is deficient.
AIM 02Assess how the liver and heart adapt to support glucose uptake in skeletal muscle with mitochondrial dysfunction.
AIM 03Examine how cellular stress responses in muscle are activated by lipid overload and impact fatty acid metabolism.
Skills the Lab Values
cell cultureanimal modelsmetabolite tracinghypoglycemic clampsisotope labelingWestern blottingPCRdata analysisbiochemical assays
Output against the department
Publications186top 35% of dept.357th of 1,033
this lab
most publishedleast published
Citations5.6kbottom 41% of dept.605th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.