Boston University · EngineeringMyelin Imaging and Neurodegeneration Unit
Irving J. Bigio · Boston, Massachusetts
Research Focus
Dr. Irving J. Bigio's lab at Boston University focuses on developing advanced imaging techniques to study myelin, the protective sheath surrounding nerve fibers, in the brain. By optimizing a method called quantitative birefringence microscopy (qBRM), the lab aims to enhance our understanding of myelin breakdown and its relation to cognitive and motor impairments in aging monkeys. The research ultimately seeks to provide new insights into neurological disorders such as Alzheimer's disease and multiple sclerosis.
myelinbirefringence microscopycognitive impairmentneurodegenerative diseasesmotor deficitsaging monkeysquantitative imagingbrain pathology
Research Aims
3AIM 01Automate the image acquisition process of brain tissues using qBRM.
AIM 02Validate qBRM measures against established myelin stains and imaging techniques.
AIM 03Quantify myelin in brain sections from monkey models with behavioral assessments related to cognitive and motor functions.
Skills the Lab Values
quantitative birefringence microscopyimage acquisition and processingmotorized stage controlmicroscopy techniquestissue preparationmyelin imagingdata analysisanimal handling (monkeys)behavioral assessment
Output against the department
Publications323top 26% of dept.71st of 278
this lab
most publishedleast published
Citations6.0kbottom 46% of dept.150th of 278
this lab
most citedleast cited
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