University of Virginia-Main Campus · BiologyGumbiner Endothelial Lab
Barry M. Gumbiner · Charlottesville, Virginia
Research Focus
Barry M. Gumbiner's lab at the University of Virginia focuses on understanding how blood vessels regulate their permeability and maintain their structure. The lab studies a specific protein called VE-cadherin that is crucial for the junctions between endothelial cells, which line blood vessels. By investigating the mechanisms that control these junctions, especially during inflammation, the lab seeks to develop new approaches to prevent tissue damage in various diseases associated with excessive blood vessel leakiness.
endothelial biologyvascular permeabilityVE-cadherininflammationcell junctionsmonoclonal antibodiesacute respiratory distress syndromeischemic strokeleukocyte diapedesis
Research Aims
5AIM 01Explore the role of VE-cadherin in regulating endothelial permeability under different physiological conditions.
AIM 02Investigate the biochemical mechanisms that control the activation of VE-cadherin.
AIM 03Examine the effects of monoclonal antibodies on barrier function in models of vascular inflammation.
AIM 04Determine how shear stress affects endothelial cell junctions.
AIM 05Analyze the interaction between VE-cadherin and the actin cytoskeleton in regulating vascular leakiness.
Skills the Lab Values
cell culturein vitro experimentationmouse modelsantibody developmentimmunofluorescencebiochemical assaysflow cytometrymolecular cloninglive-cell imaging
Output against the department
Publications152top 44% of dept.457th of 1,033
this lab
most publishedleast published
Citations29ktop 12% of dept.127th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.