Columbia University in the City of New York · Microbiology & ImmunologyBasu Immunology Lab
Uttiya Basu · New York, New York
Research Focus
Dr. Uttiya Basu's lab focuses on understanding how B cells, which are crucial for our immune system, diversify antibodies to fight infections. The lab is exploring the role of non-coding RNAs and specific protein complexes that help organize and modify the DNA in B cells during their development. Understanding these processes is important because mistakes in them can lead to immune deficiencies and cancers.
B cell developmentnon-coding RNAantibody diversificationRNA exosomeantigen receptorssomatic hypermutationclass switch recombinationgenomic integrity
Research Aims
5AIM 01Investigate the role of non-coding RNAs in B cell development
AIM 02Explore how RNA exosome influences antibody gene diversification
AIM 03Determine the effects of RNA modifications on DNA mutagenesis
AIM 04Characterize the mechanisms of somatic hypermutation in B cells
AIM 05Understand how genomic organization impacts B cell function
Skills the Lab Values
cell culturemouse modelsRNA sequencingWestern blotgenomic analysisbiochemical assaysimmunological assaysPCRbioinformaticschromatin immunoprecipitation
Output against the department
Publications80bottom 26% of dept.358th of 486
this lab
most publishedleast published
Citations4.1kbottom 32% of dept.332nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.