University at Buffalo · PharmacologyLung Cancer Biomarkers Laboratory
Philip Lazarus · Buffalo, New York
Research Focus
Dr. Philip Lazarus's lab focuses on understanding how tobacco-related chemicals contribute to lung cancer, particularly through the metabolism of specific compounds called nitrosamines. They aim to identify genetic and phenotypic markers that can help predict lung cancer risk in smokers, using diverse cohort studies. This research could lead to new prevention strategies for lung cancer, particularly for high-risk populations.
lung cancertobacco carcinogensNNKbiomarkersgenetic markerschemo-preventionpopulation studiestoxicology
Research Aims
5AIM 01Investigate the relationship between urinary NNAL enantiomers and lung cancer risk.
AIM 02Identify genetic variants influencing NNAL metabolism in smokers.
AIM 03Evaluate different populations to assess variability in lung cancer risk.
AIM 04Develop phenotypic markers for high-risk smokers.
AIM 05Explore the role of detoxification pathways in tobacco-induced carcinogenesis.
Skills the Lab Values
genetic polymorphism analysiscohort study designurinary biomarker analysisglucuronidation assayscarcinogen metabolism studiesstatistical analysisdata interpretationmolecular biology techniques
Output against the department
Publications505top 10% of dept.48th of 462
this lab
most publishedleast published
Citations14ktop 27% of dept.124th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.