UCUniversity of Cincinnati-Main Campus · Biology
Davidson Cholesterol Lab
W Sean Davidson · Cincinnati, Ohio
Research Focus
Dr. W Sean Davidson's lab at the University of Cincinnati focuses on understanding high-density lipoproteins (HDLs), often referred to as 'good cholesterol.' The lab aims to explore how different HDL forms function in protecting against heart disease and diabetes. Through a combination of laboratory experiments and computational modeling, the team investigates the molecular mechanisms of cholesterol transport and the role of specific HDL particles in cardiovascular health.
HDLcholesterol effluxcardiovascular diseaseABCA1diabetes
Research Aims
3AIM 01Investigate the interactions between ApoA-I and ABCA1 in HDL formation.
AIM 02Explore the mechanisms by which HDL particles promote cholesterol efflux.
AIM 03Analyze the structural differences among HDL subspecies in a diabetic context.
Skills the Lab Values
calibrated ion mobility spectrometrycryoelectron microscopymolecular modelingcell culturelipoprotein quantitation
Output against the department
Publications264top 23% of dept.232nd of 1,033
this lab
most publishedleast published
Citations12ktop 30% of dept.307th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.