University of California-Davis · PharmacologyMorotti Lab
Stefano Morotti · Davis, California
Research Focus
Dr. Stefano Morotti's lab focuses on understanding heart failure with preserved ejection fraction (HFpEF), a condition affecting many, particularly women. The lab combines experimental and computational techniques to investigate how the disease varies among patients and to identify potential new treatments. By studying the cellular mechanisms behind HFpEF, they aim to develop more effective therapies tailored to different patient profiles.
heart failureHFpEFphenotypic heterogeneitycomputational modelingarrhythmogenesisprecision medicinecardiac functiontranscriptomicsdrug discovery
Research Aims
4AIM 01Identify key molecular and cellular changes in HFpEF using a preclinical animal model.
AIM 02Investigate the impact of HFpEF heterogeneity on disease mechanisms and therapy.
AIM 03Develop refined modeling platforms to predict experimental outcomes and translate findings.
AIM 04Classify and discriminate cardiac phenotypes using mechanistic modeling and data-driven techniques.
Skills the Lab Values
computational modelingdata analysiscell culturemouse modelselectrophysiologytranscriptomic analysisbiophysics techniquesmechanistic modelingexperimental design
Output against the department
Publications128bottom 36% of dept.293rd of 462
this lab
most publishedleast published
Citations2.1kbottom 15% of dept.393rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.