Michigan State University · Microbiology & ImmunologyViral Oncology and Immunotherapy Lab
Dohun Pyeon · East Lansing, Michigan
Research Focus
Dr. Dohun Pyeon's lab focuses on understanding how certain viruses, specifically human papillomaviruses (HPV), contribute to the progression of head and neck cancers. They aim to uncover the mechanisms that allow these cancers to evade the immune system, particularly by studying a specific protein that degrades immune receptors, which helps tumor cells escape detection. By targeting these pathways, the lab seeks to develop new immunotherapies that could improve treatment outcomes for patients with HPV-related head and neck cancers.
HPVhead and neck cancerimmunotherapyimmune evasiontumor microenvironment
Research Aims
3AIM 01Investigate how MARCHF8 contributes to the degradation of immune receptors in HPV+ HNSCC cells.
AIM 02Explore how targeting MARCHF8 can enhance anti-tumor immunity in the tumor microenvironment.
AIM 03Develop new immunotherapy strategies that target the MARCHF8-autophagy pathway.
Skills the Lab Values
cell cultureCRISPRmouse modelsimmunohistochemistryflow cytometry
Output against the department
Publications67bottom 19% of dept.390th of 486
this lab
most publishedleast published
Citations9.1ktop 40% of dept.193rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.