Icahn School of Medicine at Mount Sinai · NeuroscienceThe Memory Nexus
Roger L Clem · New York, New York
Research Focus
Dr. Roger L. Clem's lab focuses on understanding how the brain processes conflicting memories of threat and safety, particularly through the role of specific neurons in the hippocampus. The research aims to uncover mechanisms behind fear memory extinction, which is essential for overcoming trauma. By studying these processes, the lab hopes to contribute insights that can improve therapeutic approaches for individuals dealing with pathological fear, such as those suffering from anxiety and PTSD.
fear learningmemory extinctionsomatostatin interneuronshippocampusfear recallpsychiatric disordersneural circuitscontextual memorytrauma recovery
Research Aims
4AIM 01Investigate the role of somatostatin interneurons in the ventral hippocampus during fear extinction.
AIM 02Understand how competing memories of threat and safety influence behavior.
AIM 03Examine the mechanisms that control transitions between fear and safety states in the brain.
AIM 04Elucidate the neural circuit dynamics that regulate memory retrieval and extinction.
Skills the Lab Values
electrophysiologyoptogeneticscalcium imaginggenetic manipulationanimal modelsdata analysisimmunohistochemistrybehavioral assayscell culture
Output against the department
Publications52bottom 11% of dept.590th of 671
this lab
most publishedleast published
Citations3.3kbottom 24% of dept.509th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.